I knew from the start when I got into appaloosas that they were more prone to eye problems and "moon blindness" I was wondering if anyone knows of any carting blood line of appaloosas that have more eye problems than others.

When I was breeding appaloosas (years ago) I had a gorgeous peace ck leopard stud-which we discovered, as a 3 year old was blind in one eye-and I knew he had a 1/2 sister that also had sight problems (much more severe). I told the sire owner-who adamantly denied it-but by the age of 17 he was almost completely blind and has also sired a couple more sight-hindered foals.
Then I happened across other colt-black blanketed-totally different lines-and he was blind in one eye.
I'm not sure of which lines are more prone to it-or if that is even the case.
There seems to be a lack of consensus on this one and if some one has a conclusive evidence for a genetic link, I would appreciate knowing it.
It's very touchy blaming certain bloodlines or even a breed.
Blindness is caused by several factors from poor nutrition, lepton infections or by parasites. I raise apps and have wondered about this but have no
evidence for a genetic link. I have one night-blind filly and an old time appaloosa’s man told I...that was because of her blue-specked eye.
I will only reveal her bloodline to private messages.
There is a study going on currently on this very subject. Hopefully there will be a paper out in a year or so (academic wheels grind very slowly).

There IS a genetic eye problem in Apps but I don't know how common it is because you have it lumped in with non-genetic components (eye cancers, parasites, etc.)
I'm afraid I can't help you. I've owned Appaloosas since 1973, and I've never had one with moon blindness. Years ago I had a mare with squalors cell carcinoma in one eye. Also a mare that was night blind, but she was a solid non-characteristic. I have a horse now that's blind in one eye, but that was from an accident as a foal.

Few-spots do tend to have impaired night vision, but it isn't moon blindness.

I have not heard of a specific line, either, that moon blindness and such is related to. We have owned, raised, bred, boarded quite a few Appaloosas over the years and have never had one with moonblindness. Like Gill said, we had one around for a while that was partially blind in one eye due to an injury, but that was it.

One of the most common eye problems in horses is chronic uveitis, or intraocular inflammation (it´s the same = Moon Blindness, Equine Periodic Ophthalmia, ERU).
The technical term for this disease is Equine Recurrent Uveitis (ERU).

The causes of ERU are not nailed down, unfortunately. ERU is a non-specific, immune-mediated disease that results in repeat episodes of attacks of inflammation of the eye or eyes.
There is a current theory, it says that the body develops antibodies to certain infectious organisms, such as the organisms causing leptospirosis, a bacterial infection, and onchocerciasis, a parasitic infection (many other infectious diseases including viral diseases can also trigger ERU). These antibodies are produced by a special white blood cell called a T-lymphocyte. and the antibodies may mistakenly attack tissues in the eye, creating inflammation. The antibodies can continue to attack the eyes months and years after the organism has left the body, either constantly, or intermittently. With each new ERU attack, the eyes are more and more painful and undergo more damage.
However, not all horses with antibodies to some of these organisms will develop ERU.

Genetics play a role too, and unfortunately, Appaloosas with antibodies to Leptospira are 8 times more likely than other breeds to develop ERU and 4 times more likely to become blind as a result of the ERU.